Endocrine Abstracts

Background: Primary autoimmune hypophysitis (PAH) is a rare chronic inflammatory condition of the pituitary gland that occurs more commonly in females during pregnancy or in the post-partum period. It is strongly associated with other autoimmune disorders. The various forms of hypophysitis are misdiagnosed as pituitary adenoma in 40% cases.Objective: First of all, we propose to present a case of PAH associated with other autoimmune diseases. Our second a...

Normocalcemic primary hyperparathyroidism (NPH) is characterized by normal total and ionized serum calcium concentrations and consistently elevated PTH levels. These patients have no obvious causes for secondary elevations of PTH, such as renal disease, vitamin D deficiency or malnutrition. The group consisted of 22 postmenopausal women, six premenopausal women, and two men, aged 58±2 years (range 31–77) investigated between 2011 and 2016.Resul...

Introduction: Paget’s disease of bone (PDB) is the second-most-common metabolic bone disease, after osteoporosis, affecting about 3% of the population at age over 40 years. This disease is characterized by excessive and abnormal bone remodeling due to increased bone resorption followed by disorganized bone formation.This paper will include a case report and a review of PDB epidemiology and pathophysiology, complications and clinical findings, indica...

Thyroid disease is common among the population, and the prevalence increases with age. In patients with type 1 diabetes mellitus (T1DM) the risk of thyroid dysfunction and thyroid autoimmunity is increased. The aim of this study was to investigate the relationship between thyroid function and T1DM duration. There were evaluated 110 patients (71 women and 39 men) with T1DM between 2013 and 2015 and were appreciated antibodies against thyroid peroxidase (ATPO) (normal values...

Background: Hypoglycaemia is a common complication of diabetes which causes great anxiety in patients and their families. Asymptomatic hypoglycaemia can be debilitating, especially in young children. All patients who attend Children and Young People (CYP) Diabetes Clinic have their blood glucose tested. If hypoglycaemia is identified (Blood Glucose less than 4 mmol/l), the local hypoglycaemia hospital policy should be followed by staff to provide safe and effective treatment.<...

Introduction: Neuroendocrine tumours (NET) represent ~20% of all primary neoplasms of the lung. Histologic confirmation is important for treatment and prognosis determination. NET are classified according to four subtypes in the lung: typical carcinoid tumour (TC), atypical carcinoid tumour (AC), small cell carcinoma (SCC), and large cell neuroendocrine carcinoma (LCNEC). TC is low-grade, AC is intermediate-grade, and SCC and LCNEC are high-grade malignancies.<p class="abs...

Introduction: Gestational diabetes insipidus (GDI) is a rare endocrinopathy whose incidence is around four cases per 100 000 pregnancies. It is a potentially life threatening state. We present a case of a 39 year old with GDI.Case report: A previously healthy 39-year-old woman in her 37th week of gestation presented dry oral mucosa with polydipsia and polyuria of 8 l over 24 h for approximately 2 month. The prenatal course of the pregnancy was uncomplica...

Introduction: Neuroendocrine tumors (NET) represent ~20% of all primary neoplasms of the lung. Histologic confirmation is important for treatment and prognosis determination. NET are classified according to four subtypes in the lung: typical carcinoid tumor (TC), atypical carcinoid tumor (AC), small cell carcinoma (SCC), and large cell neuroendocrine carcinoma (LCNEC). TC is low-grade, AC is intermediate-grade, and SCC and LCNEC are high-grade malignancies.<p class="abstex...

Clear cell renal carcinoma (CCRC) is a tumor with great metastatic capacity, although the presence of metastases in the thyroid gland is very uncommon. Therefore it is important to know the oncological background of the patient and to perform a complete immunohistochemical analysis of the thyroid lesion to obtain a correct diagnosis. Thyroidectomy can be considered in patients with no other metastasis or in those who present compressive symptoms as a palliative measure. We pre...

Autoimmune polyglandular syndromes (APS) are characterized by the association of two or more endocrine and/or nonendocrine autoimmune diseases with different immunologic features of their pathogenesis.Based on the clinical picture is divided into four different types. Type I APS comprises mucocutaneous candidiasis, hypoparathyroidism and Addison’s disease. Type II APS is defined by autoimmune Addison’s disease in association with chronic autoim...